Treatment for Salicylate Toxicity

The treatment for Salicylate Toxicity include pre hospital care, emergency department care, consultations, medications.

Prehospital Care

Prehospital care can be very handy especially when the toxic exposure occurs outside the hospital. It essentially include the following instructions:

  • Stabilise the airway, breathing and also circulation.
  • Evidence-based guidelines are available from the American Association of Poison Control Centers regarding the management of out of hospital salicylate exposure.

Emergency Department Care

The main objective during an emergency situation include the following:

  • cardiopulmonary stabilisation
  • Prevention of toxin absorption
  • Rectifying the fluid deficits
  • Rectifying the acid-base imbalances
  • Facilitation of quick and complete excretion of toxins

Endotracheal Intubation:

Endotracheal intubation is carried out (inserting a flexible plastic tube into the trachea through the mouth) for the following purposes:

  • For providing ventilatory support in patients with severe hypoxemia.
  • Providing hyperventilation as a measure of metabolic acidosis.
  • In patients who are agitated during central placement, hemodialysis other essential medical procedures without anaesthesia.
  • Protection of airways against the lavage, administration of activated charcoal.


Large bore vascular access catheters to facilitate emergent hemodialysis.

Methods to Prevent Aborption of Salicylate Toxins

The following methods are used to protect the adsorption:

  • Emesis
  • Gastric lavage
  • Multidose activated charcoal
  • Cathartics (substance which accelerates of defecation)

Repeated dose of cathartics should be avoided as it results in electrolyte imbalances.

Medication for Salicylate Toxicity

Drug therapy includes the following options. They are:

  • Activated charcoal
  • Sodium bicarbonate
  • Polyethylene glycol solution

Gastrointestine (GI) decontaminants are popularly used to to limit the absorption of ingested salicylate toxins.

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